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Tissue Digestion - The Tissue Digestion Process

> Chemistry of the WR2 Process
> Composition of Animal Tissues
> Effects of Alkaline Hydrolysis
> Results of the WR2 Process
> Applications of the WR2 Process
> Aldehyde-Containing Fixatives and Embalming Fluids
> Infectious Waste
> Biological Warfare Agents
> Chemotherapeutic Agents
> Control and Safety Systems

Chemotherapeutic Agents

The U.S. Environmental Protection Agency has classified eight commonly used chemotherapeutic (antineoplastic) drugs as “U-Listed Hazardous Wastes” (40CFR262.22I). The BioSAFE/WR2 Process destroys all of these agents, converting them to nontoxic compounds. Figure III-5 illustrates the destruction of antineoplastic drugs based on nitrogen mustards by the BioSAFE/WR2 Process based on their reaction with excess amino acids at high pH.

Table III-4

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Figure III-5

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Other alkylating agents that are similar to the nitrogen mustards are destroyed in the same manner. Other agents are destroyed as shown in Figure III-6. Chemical warfare agents based on nitrogen mustard, as well as most nerve gases and tear gases are also destroyed by hot alkali solutions. Note: The U.S. EPA U-listing process, which originally classified these eight agents, has not added to this list any of the new agents that have since been developed. All cytotoxic agents should be treated as hazardous.

Figure III-6 Arrows indicate sites of attack by alkali or amino groups of peptides

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